Endocrine Abstracts

Introduction: Obesity and metabolic disturbances constitute an important health problem in elderly women. Due to the multifactorial background of these disorders, assessment of the interaction between risk factors is still a significant element of prevention and health promotion in this group. Studies have shown, inter alia, the relationship between low physical activity and vitamin D deficiency with obesity and its complications. Furthermore vitamin D influences production of...

Postmenopausal osteoporosis is a condition that appears as a result of a sudden reduction in E2 production by the ovaries. The earliest is manifested by the reduction of lumbar BMD; mostly consisted of trabecular bone. Proximal femur is built mostly of cortical bone, and so is aging more slowly, but femoral fracture more often lead to disability and death. The aim of the study was to check which from the anthropometric, hormonal and biochemical markers have the infl...

The aim of this study was to determine whether polymorphisms (TaqI, ApaI, BsmI, and FokI) of the vitamin D receptor (VDR) show a correlation with the serum level of the testosterone in the aging men population.A group of 224 men aged 65–90 years, randomly selected from the group of 5695 persons included in the PolSenior project was studied. We established genotype prevalence of the VDR gene polymorphisms (TaqI, rs10735810; ApaI, rs1544410; BsmI, rs7...

Recently, low serum adiponectin levels is created as a new risk factor for cardiovascular diseases in climacteric women. Our previous study shows that smoking, serum testosterone levels, blood pressure and BMI have the influence on serum adiponectin levels. Endocannabinoid system plays a role in regulation of food intake and fat accumulation, as well as lipid and carbohydrate metabolism. Menopause transition is related to metabolic disorders (e.g. obesity) and cause the increa...

Introduction: Relationships between vitamin D and male fertility are not fully elucidated. Studies in infertile/subfertile subjects suggest that vitamin D status may be associated with semen parameters (1, 2). Data from healthy men is inconclusive (3, 4). Our purpose was to evaluate the andrological status and a range of biochemical, dietary and lifestyle variables in healthy men aged 18–35, living in the region of Lower Silesia (Poland) (AndroLS).M...

Introduction: Polycystic ovary syndrome (PCOS) is associated with metabolic disorders such as insulin resistance, hyperinsulinemia, dyslipidemia and central obesity which increase the risk of cardiovascular diseases (CVD). Lipid accumulation product (LAP) and waist circumference to height ratio (WHtR) are novel CVD risk predictors based on the assessment of waist circumference, height and serum triglycerides. The aim of our study was to evaluate the LAP and WHtR associations w...

Aggravation of the symptoms of Alzheimer’s disease may also underlie the functioning of receptors associated with calcium and vitamin D. Therefore, it seems reasonable to study the correlation of polymorphisms of vitamin D receptor (VDR) and calcium receptor (CASR) with symptoms of AD. Alzheimer’s disease, vitamin D deficiency and osteoporosis often coexist in the patient. Research suggests that vitamin D deficiency is much more frequent in the patients with AD. Expr...

Objective: To measure the levels of 25-hydroxyvitamin D (25(OH)D) and vitamin D binding protein (VDBP) and assess their relationships with metabolic features in patients with the polycystic ovary syndrome (PCOS).Methods: 267 women, aged 20–35 years (24.7±4.9): 167 with PCOS, 100 healthy women as a control group were studied. Study groups were divided according to body mass index (BMI). Biochemical and hormonal parameters, 25(OH)D, VDBP were mea...

Glypican-4 (Gpc-4) is novel adipokine interact with insulin receptor and affects insulin sensitivity in proteoglycans. Gpc-4 serum levels show gender differences; females having higher levels than men, what can suggest mediation by sex hormones. We investigated serum Gpc-4 levels and its association with cardiovascular risk predictors in women (20–35 years old) with PCOS (n=62) and healthy control (n=43) presented different sex hormones profile. The foll...

The endocannabinoid system has been suspected to contribute to the association of visceral fat accumulation with metabolic diseases. Insulin resistance play important role in etiology in PCOS. The aim of our study was developed the role of CNR1 polymorphisms (rs806368, rs12720071, rs1049353, 806381, rs10485170, rs6454674, rs2023239) in metabolic disorders in woman with PCOS. 88 woman (20–35 years old) with PCOS (recognized using Rotterdam criteria) and 77 woman (20–3...